Cytochrome P450 enzymes: A driving force of plant diterpene diversity
نویسندگان
چکیده
منابع مشابه
Triterpene Structural Diversification by Plant Cytochrome P450 Enzymes
Cytochrome P450 monooxygenases (P450s) represent the largest enzyme family of the plant metabolism. Plants typically devote about 1% of the protein-coding genes for the P450s to execute primary metabolism and also to perform species-specific specialized functions including metabolism of the triterpenes, isoprene-derived 30-carbon compounds. Triterpenes constitute a large and structurally divers...
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Many biochemical approaches have been applied to the human cytochrome P450 enzymes, and more than 20 different gene products have been characterized with regard to their properties and catalytic specificities. The complement of the various cytochrome P450 enzymes in a given individual varies markedly, and dramatic differences may be seen in drug metabolism, pharmacological response, and suscept...
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There is an increasing demand for versatile and ubiquitous Cytochrome P450 (CYP) biocatalysts for biotechnology, medicine, and bioremediation. In the last decade there has been an increase in realization of the power of CYP biocatalysts for detoxification of soil and water contaminants using transgenic plants. However, the major limitations of mammalian CYP enzymes are that they require CYP red...
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To the Editors: McFadyen et al. (1) have contributed a review on the aspects of cytochrome P450–related tumor therapy that is worth reading. It clearly shows the potential of such an approach for cancer therapy. Based on my own experience, I would kindly like to point out a few additional issues that may add to the excellent review. Ifosfamide and cyclophosphamide both use some more cytochrome ...
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Since the initial reports that renal cytochrome P450 (CYP) enzymes can metabolize arachidonic acid to substances which affect arterial tone, it has become increasingly clear that CYP enzymes expressed within the cardiovascular system play a crucial role in the modulation of vascular homeostasis. There is strong evidence suggesting that the activation of a CYP epoxygenase in endothelial cells is...
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ژورنال
عنوان ژورنال: Phytochemistry
سال: 2019
ISSN: 0031-9422
DOI: 10.1016/j.phytochem.2018.12.003